A new multiple C-slotted microstrip patch antenna is proposed in the present study. A patch antenna is a wide-beam narrowband antenna. The microstrip patch antenna consists of a very thin metallic strip (patch) placed a small fraction of a wavelength above a ground plane. The patch can be designed in any possible shape and normally made of conducting materials such as copper or gold. This study presents a design of a C-Slotted microstrip patch antenna for multiple applications. The proposed antenna's characteristics include a low cost, easy fabrication and good isolation along with Quad different frequency bands which are centered at 1.60 GHz, 2.50 GHz, 4.70 GHz and 5.50 GHz for parameter S11. The antenna is designed, simulated, and optimized for Quad band performance by using IE3D software. The C-shape-slotted patch antenna is designed on a FR4 substrate with the thickness of 1.59 mm and the relative permittivity of 4.4. The proposed patch dimension is 16*16 mm and it utilizes the microstrip line feed. The simulated results parameter S11 and S12, shows that the antenna can cover the bands of several applications including GPS (1.2-1.6 GHz), GSM (1.8-1.9 GHz) and WiMAX (2.3-5.8 GHz). Simulation results are presented in terms of Resonant Frequency, Return Loss, Voltage Standing Wave Ratio (VSWR) and Radiation Pattern.