Journal of Applied and Computational Mechanics

Numerical Investigation of Tissue-Temperature Controlled ‎System in Thermal Ablation: A Finite Element Approach

Document Type : Research Paper

Authors

Department of Industrial and Production Engineering, Shahjalal University of Science and Technology,‎ Sylhet, 3114, Bangladesh

Abstract

In thermal ablation, several techniques of treating infected cell in human tissue are being used by the physicians. Transferring heat to the infected cell is one of them. The purpose of this research is to investigate the tissue-temperature controlled system in thermal ablation and compare with two different point heating processes, namely constant and step heating. For this purpose, the finite element model of Penne’s bio-heat equation has been developed to measure the temperature within the two-dimensional tissue model embedded with a small tumor. The tissue temperature-controlled heating was designed to restrict the healthy tissue temperature below the damage threshold temperature. Using the temperature profile, tissue damage index was measured with the help of Arrhenius rate equation. The results show that the tissue temperature-controlled system reduces the temperature of healthy tissue nearby the infected cell to 40% compare to constant and step point heating. This system keeps the healthy tissue within the threshold value (43oC) up to 1000s when it is 100s for other two techniques. After 200s, healthy tissue nearby the infected cell start to damage for constant and step point heating. But temperature-controlled system always keep the healthy tissue safe. The results of this research conclude the temperature-controlled system a better heating technique to remove the infected cell. The information published in this paper will be helpful for the physicians and bio-medical engineers to treat the infected cell or to design medical equipment.

Keywords

Main Subjects

Publisher’s Note Shahid Chamran University of Ahvaz remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

[1] Simon, Caroline J., Damian E. Dupuy, and William W. Mayo-Smith, Microwave ablation: principles and applications, Radiographics, 25, 2005, S69-S83.
[2] Tang, Yun-dong, Tao Jin, and Rodolfo CC Flesch, Effect of mass transfer and diffusion of nanofluid on the thermal ablation of malignant cells during magnetic hyperthermia, Applied Mathematical Modelling, 83, 2020, 122-135.
[3] Saiyed, Z. M., S. D. Telang, and C. N. Ramchand, Application of magnetic techniques in the field of drug discovery and biomedicine, BioMagnetic Research and Technology, 1(1), 2003, 1-8.
[4] Chu, Katrina F., and Damian E. Dupuy, Thermal ablation of tumours: biological mechanisms and advances in therapy, Nature Reviews Cancer, 14(3), 2014, 199-208.
[5] Ortega-Palacios, Rocío, et al., Heat transfer study in breast tumor phantom during microwave ablation: Modeling and experimental results for three different antennas, Electronics, 9(3), 2020, 535.
[6] Tehrani, Masoud HH, et al., Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes—A computational approach, PlosOne, 15(6), 2020, e0233219.
[7] Chowdhury, Emdadul Haque, et al., Investigation on High Frequency Based Ultrasound Tissue Therapy by Finite Element Method, 2nd International Conference on Advanced Information and Communication Technology (ICAICT), IEEE, 2020.
[8] Nikfarjam, Mehrdad, Vijayaragavan Muralidharan, and Christopher Christophi, Mechanisms of focal heat destruction of liver tumors, Journal of Surgical Research, 127(2), 2005, 208-223.
[9] Rossmann, Christian, Frank Rattay, and Dieter Haemmerich, Platform for patient-specific finite-element modeling and application for radiofrequency ablation, Visualization, Image Processing and Computation in Biomedicine, 1(1), 2012, DOI: 0.1615/VisualizImageProcComputatBiomed.2012004898.
[10] Eick, Olaf J., Temperature controlled radiofrequency ablation, Indian Pacing and Electrophysiology Journal, 2(3), 2002, 66.
[11] Langberg, Jonathan J., et al., Temperature monitoring during radiofrequency catheter ablation of accessory pathways, Circulation, 86(5), 1992, 1469-1474.
[12] Deng, Zhong-Shan, and Jing Liu, Analytical study on bioheat transfer problems with spatial or transient heating on skin surface or inside biological bodies, J. Biomech. Eng., 124(6), 2002, 638-649.
[13] Karaa, Samir, Jun Zhang, and Fuqian Yang, A numerical study of a 3D bioheat transfer problem with different spatial heating, Mathematics and Computers in Simulation, 68(4), 2005, 375-388.
[14] Pennes, Harry H., Analysis of tissue and arterial blood temperatures in the resting human forearm, Journal of Applied Physiology, 1(2), 1948, 93-122.
[15] Hristov, Jordan, Bio-heat models revisited: concepts, derivations, nondimensalization and fractionalization approaches, Frontiers in Physics, 7, 2019, 189.
[16] Mukaddes, Abul Mukid Md, et al., Finite Element-Based Analysis of Bio-Heat Transfer in Human Skin Burns and Afterwards, International Journal of Computational Methods, 2020, 2041010.
[17] Sannyal, Mridul, et al., Analysis of the effect of external heating in the human tissue: A finite element approach, Polish Journal of Medical Physics and Engineering, 26(4), 2020, 251-262.
[18] Wang, Xiaoru, et al., Numerical evaluation of ablation zone under different tip temperatures during radiofrequency ablation, Math. Biosci. Eng., 16, 2019, 2514-2531.
[19] Yarmolenko, Pavel S., et al., Thresholds for thermal damage to normal tissues: an update, International Journal of Hyperthermia, 27(4), 2011, 320-343.
[20] Pennes, Harry H., Analysis of tissue and arterial blood temperatures in the resting human forearm, Journal of Applied Physiology, 1(2), 1948, 93-122.
[21] Abraham, J. P., and E. M. Sparrow, A thermal-ablation bioheat model including liquid-to-vapor phase change, pressure-and necrosis-dependent perfusion, and moisture-dependent properties, International Journal of Heat and Mass Transfer, 50(13-14), 2007, 2537-2544.
[22] Li, Fang-fang, Jing Liu, and Kai Yue, Exact analytical solution to three-dimensional phase change heat transfer problems in biological tissues subject to freezing, Applied Mathematics and Mechanics, 30(1), 2009, 63-72.
[23] Henriques, F.C., Jr., Studies of Thermal Injuries V. The Predictability and the Significance of Thermally Induced Rate Processes Leading to Irreversible Epidermal Injury, Archives of Pathology, 43, 1947, 489-502.
[24] Davis, Trevor E., et al., Bio-Heat Transfer in Various Transcutaneous Stimulation Models, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering, 8(9), 2014, 617-623.
[25] Carslaw, Horatio Scott, and John Conrad Jaeger, Conduction of heat in solids, Clarendon Press, 1992.
[26] Cao, Leilei, Qing-Hua Qin, and Ning Zhao, An RBF–MFS model for analysing thermal behaviour of skin tissues, International Journal of Heat and Mass Transfer, 53(7-8), 2010, 1298-1307.
[27] Shen, Wensheng, Jun Zhang, and Fuqian Yang, Modeling and numerical simulation of bioheat transfer and biomechanics in soft tissue, Mathematical and Computer Modelling, 41(11-12), 2005, 1251-1265.
[28] Tungjitkusolmun, Supan, et al., Three-dimensional finite-element analyses for radio-frequency hepatic tumor ablation, IEEE Transactions on Biomedical Engineering, 49(1), 2002, 3-9.
[29] Haemmerich, Dieter, and John G. Webster, Automatic control of finite element models for temperature-controlled radiofrequency ablation, Biomedical Engineering Online, 4(1), 2005, 1-8.
[30] Cao, Leilei, Qing-Hua Qin, and Ning Zhao, An RBF–MFS model for analysing thermal behaviour of skin tissues, International Journal of Heat and Mass Transfer, 53(7-8), 2010, 1298-1307.
[31] Liu, Jing, and Lisa X. Xu, Boundary information based diagnostics on the thermal states of biological bodies, International Journal of Heat and Mass Transfer, 43(16), 2000, 2827-2839.
[32] Davis, Trevor E., et al., Bio-Heat Transfer in Various Transcutaneous Stimulation Models, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering, 8(9), 2014, 617-623.
[33] Stoll, Alice M., and Leon C. Greene, Relationship between pain and tissue damage due to thermal radiation, Journal of Applied Physiology, 14(3), 1959, 373-382.
Journal of Applied and Computational Mechanics
Volume 7, Issue 3
July 2021
Pages 1826-1835